In clinical trialsRecruiting· Pilot RCT
MEOW-1 — OKV-119 in overweight/obese cats
🇺🇸 USA (San Francisco) · Cats · Overweight / obesity (GLP-1 weight loss)
Randomized, placebo-controlled trial of OKV-119, an ultra-long-acting exenatide implant delivering a GLP-1 agonist for up to 6 months from a single in-office implant, in ~50 client-owned overweight/obese cats. First cat dosed December 2025. FDA filing targeted 2027–2028. First-ever GLP-1 weight-loss trial in cats or dogs.
OKAVA Pharmaceuticals · VeterinaryClinicalTrials.org · OKAVA press release
In clinical trialsUnderway· Review / preclinical
Anorexigenic & orexigenic peptides for companion-animal obesity
🌐 Multi-country · Dogs & Cats · Energy-balance management
Active review and research into ghrelin, GLP-1, leptin, nesfatin-1, phoenixin, asprosin for energy-balance management in companion animals.
Multi-institution review · Open-access review · NCBI PMC11275339
In clinical trialsUnderway· Preclinical → early clinical
Antimicrobial peptides as targeted anti-infectives
🌐 Multi-country · Companion & livestock · Resistant infections — AMR response
Investigated as targeted anti-infectives amid the antimicrobial-resistance crisis in companion animals and livestock.
Multi-institution · Companion & livestock research consortia · PeptideJournal · Wiley AMR review
Standard-of-careCompleted· Standard-of-care
DDAVP for von Willebrand's disease — canine surgical hemostasis
🌐 Multi-country · Dogs · vWD bleeding control
Transiently raises vWF and shortens bleeding time in von Willebrand's disease, enabling surgery/bleeding control. Feline hemostatic effect not yet established.
Established clinical use · Veterinary teaching hospitals · Bachem — Peptides in Veterinary Medicine
Standard-of-careCompleted· Validated diagnostic
NT-proBNP — validated cardiac biomarker in dogs & cats
🇧🇷 Brazil · Dogs & Cats · Diagnose/monitor CHF
Validated cardiac biomarker for diagnosing and monitoring congestive heart failure in dogs and cats; fast in-clinic assays available.
Veterinary World · Open-access publication · de Lima & Ferreira, Veterinary World 2017
In clinical trialsUnderway· Uncontrolled clinical practice
Tβ4 / TB-500 in equine tendon & ligament practice
🐎 Multi-country · Horses · SDFT / suspensory ligament recovery
Active clinical use, largely uncontrolled. Detection methods exist in equine plasma/urine; banned in many racing jurisdictions — verify before use.
Equine sports-medicine practitioners · Multi-country clinical use · Mad Barn · J. Chromatogr. A 2012
InvestigationalPreclinical· Bench → translational
Recombinant Tβ4 for wound healing — preclinical
🇨🇳 China · Preclinical models · Dermal & soft-tissue healing
Recombinant Tβ4 wound-healing research; supports mechanistic basis for Tβ4-fragment translational programs.
Shanghai Jiao Tong University · PMC3671520 · PMC4963596
InvestigationalPreclinical· Preclinical
BPC-157 — ligament/GI repair (rodent models)
🌐 Multi-country · Rodent (preclinical) · Connective tissue & GI
Virtually all published evidence is from rodent models. Not approved for veterinary use. Used in some integrative canine practices under veterinary discretion.
Multi-academic · Multiple research groups · PeptideJournal · CIVT webinar
